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廖晨钟
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姓 名:
廖晨钟
职 称:
教授
职 务:
所属系:
药学系
邮 箱:
czliao@hfut.edu.cn
电 话:
182-5600-7962
个人学习工作简介
       廖晨钟博士,合肥工业大学医学工程学院教授,兼任美国国家健康研究院(National Institutes of Health)癌症研究所(National Cancer Institute)客座研究员(Guest Researcher)。专长于小分子化学药物设计与合成、化学信息学及新药研发,在抗恶性肿瘤药物、抗艾滋病药物及抗2型糖尿病药物的研发方面具有丰富的经验。2004年6月毕业于中国科学院过程工程研究所,获化学工艺博士学位(研究方向:计算机辅助药物设计)。之后在深圳微芯生物科技有限责任公司担任生化信息学部主任职务。2005年10月至2010年9月在美国国家健康研究院癌症研究所任访问学者(博士后)。2010年10月至2012年9月在美国密歇根大学(University of Michigan)任助理研究员。已发表论文和学术专著40余篇,申请8项国际专利和2项中国专利(各有2项已授权),参与3部国际学术专著的编写。设计的抗2型糖尿病药物和抗恶性肿瘤药物曾作为国家一类新药进入临床研究。
研究兴趣领域
1.      药物设计与合成
2.      计算机辅助药物设计
3.      化学信息学
4.      抗恶性肿瘤药物的研发、抗艾滋病药物的研发
社会兼职
1.  美国国家健康研究院癌症研究所(National Institutes of Health, National Cancer Institute)客座研究员(Guest Researcher)
2.  美国化学会(American Chemical Society)会员
3.  美国癌症研究协会(American Association for Cancer Research)会员
4.  多家国际知名杂志,如ACS Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Journal of Chemical Information and Modeling, Future Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Antiviral Research, Journal of Chemical Theory and Computation, PLoS Computational Biology, Molecular Informatics, Letters in Drug Design & Discovery, Journal of Biophysics and Structural Biology等的特约审稿人
5.  香港特区政府总部食物及卫生局科研基金的特约评审人
6.  任Current Pharmaceutical Design(影响因子4.774)杂志的Executive Guest Editor;任Current Drug Targets(影响因子3.061)杂志的Guest Editor
期刊论文
1.     Liao C, Yao R. Polo-like kinase 1 inhibitors from natural products and their structural diversity. Submitted to Science China Chemistry (中国科学-化学), 2013.
2.    Abulwerdi FA, Liao C, Mady A, Di Bernardo J, Asfar A, Cierpicki T, Stuckey J, Showalter HD, Mohammad R, Nikolovska-Coleska Z. Design, synthesis and biological evaluation of substituted sulfonamido-1-hydroxynaphthalene compounds as novel small-molecule Mcl-1 inhibitors. Prepare to submit to Journal of Medicinal Chemistry, 2013.(并列第一作者)
3.    Abulwerdi F, Liao C, Di Bernardo J, Cierpicki T. Mohammad R, Showalter HD, Nikolovska-Coleska Z. UMI-77: a novel, selective small-molecule inhibitor of Mcl-1 for the treatment of pancreatic cancer. Molecular Cancer Therapeutics, 2013.(并列第一作者,文章已接收,修改过程中)
4.    Shen C, Liao C, Jo SY, Cierpicki T, Hess JL, Nikolovska-Coleska Z*. Targeting recruitment of Disruptor Of Telomeric silencing 1-Like (DOT1L): Characterizing the interactions between DOT1L and MLL-fusion proteins. Journal of Biological Chemistry, 2013.(文章已接收,出版过程中)
5.    Sitzmann M, Weidlich IE, Filippov IV, Liao C, Peach ML, Ihlenfeldt W-D, Karki RG, Borodina YV, Cachau RE, Nicklaus MC. PDB Ligand Conformational Energies Calculated Quantum-Mechanically. Journal of Chemical Information and Modeling, 2012, 52, 739-756.
6.    Bajwa N, Liao C, Nikolovska-Coleska Z. Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review. Expert Opinion on Therapeutic Patents, 2012, 22, 37-55.
7.    Liao C, Sitzmann M, Pugliese A, Nicklaus MC. Software and Resources for Computational Medicinal Chemistry. Future Medicinal Chemistry, 2011, 3, 1123-1140.(通讯作者)
8.   Yao Z, Xu Y, Zhang M, Jiang S, Nicklaus MC, Liao C. Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-reductase Inhibitor. Bioorganic & Medicinal Chemistry Letters, 2011, 21, 475-478.(通讯作者)
9.   Liao C, Park J-E, bang JK, Nicklaus MC, Lee KS. Probing Binding Modes of Small Molecule Inhibitors to the Polo-Box Domain of Human Polo-like Kinase 1. ACS Medicinal Chemistry Letters, 2010, 1, 110-114.
10.  Liao C, Nicklaus MC. Computer Tools in the Discovery of HIV-1 Integrase Inhibitors. Future Medicinal Chemistry, 2010, 2, 1123-1140.
11.  Liao C, C. Marchand, T. R. Burke, Jr., Y. Pommier, Nicklaus MC. Authentic HIV-1 Integrase Inhibitors. Future Medicinal Chemistry, 2010, 2, 1107-1122.
12.   Zeng X, Yin B, Hu Z, Liao C, Liu J, Li S, Li Z, Nicklaus MC, Zhou G, Jiang S. Total Synthesis and Biological Evaluation of Largazole and Derivatives with Promising Selectivity for Cancers Cells. Organic Letters, 2010, 12, 1368-1371.
13.   Liao C, Nicklaus MC. Tautomerism and Magnesium Chelation of HIV-1 Integrase Inhibitors: A Theoretical Study. ChemMedChem, 2010, 5, 1053-1066.
14.  Park J-E, Soung N-K, Yoshikazu J, Kang YH, Liao C, Lee KH, Park C-H, Nicklaus MC, Lee KS. Polo-box domain: A Versatile Mediator of Polo-like Kinase Function. Cellular and Molecular Life Sciences, 2010, 67, 1957-1970.
15.  Liao C, Nicklaus MC. Comparison of Nine Programs Predicting pKa Values of Pharmaceutical Substances. Journal of Chemical Information and Modeling, 2009, 49, 2801?2812.
16.  Druzhilovsky DS, Filimonov DA, Liao C, Peach M, Nicklaus MC, Poroikov VV. Computer-assisted search and optimization of new human immunodeficiency virus integrase inhibitors. Biomeditsinskaya Khimiya (Biomedical Chemistry), 2009, 55, 544-557.
17.  Yun S-M, Moulaei T, Lim D, Bang JK, Shenoy SR, Park J-E, Liu F, Kang YH, Liao C, Soung N-K, Lee S, Yoon DY, Lim Y, Lee D-H, Otaka A, Appella E, James B, Mahon JB, Nicklaus MC, Burke TR, Yaffe MB, Wlodawer A, Lee KS. Structural and functional analyses of a minimal phosphopeptide targeting the polo-box domain of polo-like kinase 1. Nature Structural & Molecular Biology, 2009, 16, 876-883.
18.  Jiang S, Liao C, Bindu L, Yin B, Worthy KW, Fisher RJ, Nicklaus MC, Roller PP. Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 2693-2698.
19.   Ludek O, Schroeder GK, Liao C, Russ PL, Wolfenden R, Marquez VE. Synthesis and conformational analysis of locked carbocyclic analogues of 1,3-diazepinone riboside, a high-affinity cytidine deaminase inhibitor. Journal of Organic Chemistry, 2009, 74, 6212-6223.
20.  Boyer PL, Vu BC, Ambrose Z, Julias JG, Warnecke S, Liao C, Meier C, Marquez VE, Hughes SH. The Nucleoside Analog D-carba T Blocks HIV-1 Reverse Transcription. Journal of Medicinal Chemistry, 2009, 52, 5356-5364.
21.  Comin MJ, Vu BC, Boyer PL, Liao C, Hughes SH, Marquez VE. D-(+)-iso-Methanocarbathymidine, a high affinity substrate for herpes simplex virus 1 thymidine kinase. ChemMedChem, 2008, 3, 1129-1134.
22.  Liao C, Karki RG, Marchand C, Pommier Y, Nicklaus MC. Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA. Bioorganic & Medicinal Chemistry Letters. 2007, 17, 5361-5365.
23.  Comin MJ, Agbaria R, Ben-Kasus T, Huleihel M, Liao C, Sun G, Nicklaus MC, Deschamps JR. Parrish DA, Marquez VE. Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase. Journal of the American Chemical Society, 2007, 129, 6216-6222.
24.  Zhao XZ, Semenova EA, Liao C, Nicklaus MC, Pommier Y, Burke TR. Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands. Bioorganic & Medicinal Chemistry, 2006, 14, 7816-7825.
25.  Deng T, Shan S, LI ZB, Wu ZW, Liao C, Ben KO, Lu XP, Cheng J, Ning ZQ. A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice. Biological & Pharmaceutical Bulletin, 2005, 28, 1192-1196.
26.  Liao C, Liu B, Shi L, Zhou J, Lu XP. Construction of a virtual combinatorial library using SMILES strings to discover potential structure-diverse PPAR modulators. European Journal of Medicinal Chemistry, 2005, 40, 632-640. (通讯作者)
27.  Li Z, Liao C, Ko BCB, Shan S, Tong EH, Yin Z, Pan D, Wong VKW, Shi L, Ning ZQ, Lu XP. Design, synthesis and evaluation of novel noncyclic 1,3-dicarbonyl compounds as PPARα selective activators. Bioorganic & Medicinal Chemistry Letters. 2004, 14, 3507-3511.(并列第一作者)
28.   Liao C, Xie A, Shi L, Zhou J, Lu XP. Eigen value analysis of peroxisome proliferator-activated receptor γ agonists. Journal of Chemical Information and Computer Sciences. 2004, 44, 230-238.
29.  Liao C, Xie A, Zhou J, Shi L, Li Z, Lu XP. 3D QSAR studies on peroxisome proliferator-activated receptor γ agonists using CoMFA and CoMSIA. Journal of Molecular Modeling. 2004, 10, 165-177.
30.  Xie AH, Liao C, Li Z, Ning ZQ, Hu WM, Lu XP, Shi L, Zhou J. Quantitative structure-activity relationship study of histone deacetylase inhibitors. Current Medicinal Chemistry Anti-Cancer Agents. 2004, 4, 273-299.
31.  Xie AH, Liao C, Li Z, Ning ZQ, Hu WM, Lu XP, Shi L, Zhou J. Quantitative structure-activity relationship study of bisphosphonates. Internet Electronic Journal of Molecular Design. 2004, 3, 622-650.
32.  Liu B, Lu A-J, Liao C, Liu H-B, Zhou J-J. 3D-QSAR of Sulfonamide Hydroxamic Acid HDAC Inhibitors. Acta Phys. ? Chim. Sin. (Wuli Huaxue Xuebao). 2005, 21, 333-337.
33.  Xie AH, Li BY, Liao C, Li ZB, Lu XP, Shi LM, Zhou J. Docking study of HDAC: implication for benzamide inhibitors binding mode. Acta Phys. ? Chim. Sin. (Wuli Huaxue Xuebao). 2004, 20, 569-572.
34.  廖晨钟, 石乐明, 周家驹, 鲁先平. 一种用SMILES码构建虚拟组合化学库的新方法. 计算机与应用化学 2005, 22, 247-252.
35.  兰玉坤, 马保顺, 尹子卉, 廖晨钟, 山松, 李志良, 宁志强, 鲁先平, 李志斌. 新型胰岛素增敏剂西格列羧的合成. 中国新药杂志 2004, 13, 718-720.
36.  尹子卉, 吴仲闻, 兰玉坤, 廖晨钟, 山松, 李志良, 宁志强, 鲁先平, 李志斌. 新型抗肿瘤组蛋白去乙酰化酶抑制剂西达本胺的合成. 中国新药杂志 2004, 13, 536-538.
37. 苏振强, 潘德思, 山松, 胡伟明, 宁志强, 李志斌, 石乐明, 廖晨钟, 张大杰, 乔伟, 鲁先平. 生化信息学在药物创新过程中的重要作用. 中国新药杂志 2004, 13, 385-388.
38.  廖晨钟, 邓沱, 山松, 潘德思, 李志斌, 宁志强, 胡伟明, 石乐明, 周家驹, 鲁先平. 以PPAR为靶标的抗2型糖尿病药物研发策略. 中国新药杂志 2003, 12, 980-983.
39.  苏振强, 廖晨钟, 谢爱华, 鲁先平, 石乐明. 基于甲骨文数据库管理系统的化学结构检索数据库的设计与实现. 计算机与应用化学 2003, 20, 556-562.
专著
1. Liao C, Liao C, Peach ML, Yao R-S, Nicklaus MC. Molecular docking and structure-based virtual screening. In "In Silico Drug Discovery and Design Techniques". Future Science Group. 2013(出版过程中).
2. Liao C, Nicklaus MC. HIV-1 integrase-DNA models. In "HIV-1 Integrase: Mechanism of Action and Inhibitor Design". John Wiley & Sons, Inc. 2011, 429-455.
3. Shi LM, Su ZQ, Xie AH, Liao C, Qiao W, Zhang DJ, Shan S, Pan DS, Li ZB, Ning ZQ, Hu WM, Lu XP. An integrated biochemoinformatics system for drug discovery: managing and mining chemical structure information, biological activity fingerprints, and gene expression profiling patterns. In "Frontiers of Biochip Technologies", Xing WL and Cheng J (Editors), Springer US, Invited book chapter, 2006, 191-206.
会议论文
1.    Liao C, Mady A, Abulwerdi FA, Du Y, Fu H, Stuckey J, Cierpicki T, Nikolovska-Coleska Z. Utilization of PubChem’s BioAssay Database for Drug Discovery: Identification of Mcl-1 inhibitors with novel chemical scaffolds. 244th ACS National Meeting, Philadelphia, PA, USA. 2012, August 19-23.
2.    Abulwerdi FA, Liao C, Mady A, Di Bernardo J, Asfar A, Cierpicki T, Stuckey J, Showalter HD, Mohammad R, Nikolovska-Coleska Z. Design, synthesis and biological evaluation of substituted sulfonamido-1-hydroxynaphthalene compounds as novel small-molecule Mcl-1 inhibitors. 243th ACS National Meeting, San Diego, CA, USA. 2012, March 25 ? 29.
3.    Liao C, Park J-E, bang JK, Nicklaus MC, Lee KS. Exploring Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1. 239th ACS National Meeting, San Francisco, CA, USA. 2010, March 21 ? 25.
4.     Liao C, Lee KS, Nicklaus MC. Docking Studies and Molecular Dynamics Simulations of Inhibitors of Polo-like Kinase 1 Polo Box Domain: Implications for Design of Non-Phosphopeptide Ligands. 238th ACS National Meeting, Washington, DC, USA. 2009, August 16 ? 20.
5.    Liao C, Nicklaus MC. Theoretical Study of HIV-1 Integrase Inhibitors’ Tautomerisms and Modes of Chelation with Two Magnesium Ions. 237th ACS National Meeting, Salt Lake City, UT, USA. 2009, March 22 ? 26.
6.    Liao C, Nicklaus, MC. Models of HIV-1 integrase/DNA complex. 235th ACS National Meeting, New Orleans, LA 2008, April 6-10.(Merck公司邀请)
7.    Zhong M, Liao C, Melman A, Jacobson KA, Marquez VE. Synthesis of south locked bicyclo[3.1.0]hexane ribonucleosides to study the effect of sugar pucker on RNA cleavage. 235th ACS National Meeting, New Orleans, LA 2008, April 6-10.
8.    Liao C, Nicklaus, MC. Modeling of HIV integrase-DNA active site with two magnesium ions. 235th ACS National Meeting, New Orleans, LA 2008, April 6-10.
9.    Liao C, Nicklaus, MC. Discovery of novel HIV-1 integrase inhibitors by pharmacophore search. 234th ACS National Meeting, Boston, MA 2007, August 19-23.
10.  Zhao XZ, Semenova EA, Vu BC, Liao C, Nicklaus MC, Hughes SH, Pommier Y, Burke TR. Phthalimide-containing hydrazides and amides as diketo acid-class HIV-1 integrase inhibitors. 234th ACS National Meeting, Boston, MA 2007, August 19-23.
11.  Zhao XZ, Semenova EA, Johnson A, Marchand C, Liao C, Nicklaus MC, Hughes SH, Pommier Y, Burke TR. Click chemistry-derived biotin-tagged diketo acid-containing biphenyl ketones designed as HIV-1 integrase photoaffinity ligands. 232nd ACS National Meeting, San Francisco, CA 2006, September 10-14.
12.  Liao C, Rajeshri G, Nicklaus, MC. Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA. 232nd ACS National Meeting, San Francisco, CA 2006, September 10-14.
13.   Shi L, Su Z, Xie A, Liao C, Qiao W, Zhang D, Li Z, Ning Z, Hu W, Lu X. Integrating chemical structures, biological activity fingerprints, and gene expression profiling for drug discovery. 225th ACS National Meeting, New Orleans, LA 2003, March 23-27.
国际和国内授权专利及申请
1.    Nikolovska-Coleska Z, Showalter HD, Liao C, Abulwerdi F. Small molecule inhibitors of Mcl-1 and the uses thereof. US Provisional Patent Application No. 61/544,133. Filed: 2011-10-06.
2.    Lu XP, Li ZB, Liao C, Shi LM, Liu ZD, Ma BS, Ning ZQ, Shan S, Deng T. Substituted arylalcanoic acid derivatives as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity. Pub. No.: United States Patent 7268157. Granted/Filed: 2007-09-11/2003-11-18.(已授权专利)
3.   Lu XP, Li ZB, Liao C, Shi LM, Liu ZD, Ning ZQ, Shan S, Deng T, Ma BS. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity. Pub. No.: United States Patent 7192970. Granted/Filed: 2007-03-20/2003-11-14.(已授权专利)
4.   Lu XP, San S, LI ZB, Luo YP, Liao C, Liu ZD, Ning ZQ. Pharmaceutical compositions of flavones and long chain fatty acid derivatives isolated from plants and methods related thereto for the control of prostate disorders. Pub. No.: United States Patent 20060252708. Published/Filed: 2006-11-09/2005-05-09.
5.   Li ZB, Lu XP, Liao C, Shi LM, Liu ZD, Ma BS, Ning ZQ, Shan S, Deng T. Substituted arylalcanoic ccid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity. Pub. No.: WO2004/048333 A1. International Application No.: PCT/IB2003/005371. Published/Filed: 2004-06-10/2003-11-21.
6.   Li ZB, Lu XP, Liao C, Shi LM, Liu ZD, Ning ZQ, Shan S, Deng T, Ma BS. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity. Pub. No.: WO2004/048338 A1. International Application No.: PCT/IB2003/005294. Published/Filed: 2004-06-10/2003-11-19.
7.    鲁先平, 李志斌, 廖晨钟, 石乐明, 刘振德, 马保顺, 宁志强, 山松, 邓沱. 具有优异降糖降酯活性的芳烷基氨基酸类PPAR全激活剂. 专利号: ZL 03126974.5. 授权日期: 2006年5月31日.(已授权专利)
8.    鲁先平, 李志斌, 廖晨钟, 石乐明, 刘振德, 马保顺, 宁志强, 山松, 邓沱. 具有降糖降脂活性的非环1, 3-二羰基PPAR双激活化合物及药用制剂的制备方法. 专利号: ZL03140230.5. 授权日期: 2006年05月17日.(已授权专利)
 

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