副教授
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阮班锋
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姓 名:
阮班锋
职 称:
副教授
职 务:
硕士生导师
所属系:
药学系
邮 箱:
ruanbf@hfut.edu.cn
电 话:
0551-62901534
个人学习工作简介
2011.7-至今 合肥工业大学生物与医学工程学院 副教授 硕士生导师
2012.3-2012.7 国家食品药品监督管理局药品审评中心化药药学二部 (化学药物审评)
2009.6-2011.6 南京大学化学化工学院(博士后研究)
2004.9-2009.5 南京大学医药生物技术国家重点实验室(药物化学-理学博士)
主要研究领域与方向
1、药物分子设计与合成:以具有生物活性的天然产物为母体,结合计算机辅助药物设计,开展抗肿瘤先导化合物的设计、合成及活性评价工作;
2、制药工程:原料药开发及质量研究;
3、植物保护:绿色农药开发。
 
主讲本科生课程:《药物化学》、《中药化学》
主讲研究生课程:《高等药物化学》、《新药研发与注册管理》

研究生招生方向:
       药物化学:药物分子设计与合成
       制药工程:原料药合成及质量研究
       植物保护:微生物及病毒学
目前承担科研项目
1.  非洛地平原料药晶型研究,企业委托项目,2015.01-2015.12,主持,已结题;
2.  “蚜虫与烟草蚜传病毒病发生流行相关性及治虫防病研究”,安徽省烟草公司科技重点项目(编号:20150551007),2015.06-2018.12,主持;
3.  “靶向微管蛋白秋水仙碱位点的白藜芦醇-Combrestatin A-4 类抑制剂的设计、合成及活性研究”,国家自然科学基金青年基金(编号:21302036),2014.1-2016.12,主持;
4.  “靶向微管蛋白的白藜芦醇CA-4类似物的设计、合成及抗肿瘤活性评价”,安徽省自然科学基金面上项目(编号:1308085MB18),2013.7-2015.6,主持,已结题;
5.  “靶向烟草花叶病毒外壳蛋白的白藜芦醇衍生物的设计、合成及活性评价”,中国博士后科学基金一等资助(编号:2013M530409),2013.1-2014.12,主持;
6.  “抑制烟草青枯病菌的复合生物制剂筛选”,安徽省烟草专卖局科技委托项目(编号:20130551006),2013.09-2016.08,主持。
著作论文(代表作)
截止目前共发表第一作者和通讯作者SCI论文近30篇,近五年主要代表作如下:
1. Ban-Feng Ruan, Hui-Jie Cheng, Jing Ren, Hong-Lin Li, Lu-Lu Guo, Xing-Xing Zhang, Chenzhong Liao*. Novel 2H-chromen-2-one Derivatives of Resveratrol: Design, Synthesis, Modeling and Use as Human Monoamine Oxidase Inhibitors. Eur. J. Med. Chem. 2015, 103, 185-190.
2. Jing Ren, Si-Qi Wang, Hai-Jun Ni, Ri-Sheng Yao, Chen-Zhong Liao, Ban-Feng Ruan*. Synthesis, characterization and antitumor activity of novel ferrocene-based amides bearing pyrazolyl moiety. J. Inorg. Organomet. Polym. 2015, 25, 419-426.
3. Qing-Shan Li, Hai-jun Ni, Yang Yang, Xian-Hai Lv*, Ban-Feng Ruan*. Discovery of novel dinitrobenzotrifluoride-containing o-hydroxybenzylamine derivatives as potential antibacterial agents. Med. Chem. 2015, 11, 305-313.
4. Ban-Feng Ruan, Ying-Zhong Zhu, Wan-Ding Liu, Bao-An Song*, Yu-Peng Tian*. Synthesis, characterization, cytotoxicity and antibacterial activity of an anthracenyl-linked bis(pyrazolyl)methane ligand and its zinc(II) complexes. Eur. J. Med. Chem. 2014, 72, 46-51.
5. Xian-Feng Huang, Ling-Zhu Wang, Long Tang, Ying-Xun Lu, Fan Wang, Guo-Qiang Song, Ban-Feng Ruan*. Synthesis, characterization and antitumor activity of novel ferrocene derivatives containing pyrazolyl-moiety. J. Organomet. Chem . 2014, 749, 157-162.
6. Ri-Sheng Yao, Xiao-Qin Lu, Qiu-Xiang Guan, Lei Zheng, Xiang Lu, Ban-Feng Ruan*. Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents. Eur. J. Med. Chem. 2013, 62, 222-231.
7. Ban-Feng Ruan, Xiao-Qin Lu, Jie Song, Hai-Liang Zhu. Derivatives of resveratrol: potential agents in prevention and treatment of cardiovascular disease. Curr. Med. Chem. 19, 2012, 4175-4183.
8. Xian-Feng Huang, Jian-Feng Tang, Jun-Ling Ji, Xiao-Liang Wang, Ban-Feng Ruan*. Synthesis, characterization and antitumor activity of novel amide derivatives containing ferrocenyl pyrazol-moiety. J. Organomet. Chem. 706-707, 2012, 113-123.
9. Ban-Feng Ruan and Hai-Liang Zhu. The Chemistry and Biology of the Bryostatins: Potential PKC Inhibitors in Clinical Development. Curr. Med. Chem. 19, 2012, 2652-2664.
10. Ban-Feng Ruan, Xiang Lu, Ting-Ting Li, Jian-Feng Tang, Yao-Wei, Xiao-Liang Wang, Shi-Li Zheng, Ri-Sheng Yao*, Hai-Liang Zhu. Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing curcumin moiety as potent antitubulin agents. Bioorg. Med. Chem. 20, 2012, 1113-1121.
11. Ban-Feng Ruan, Xiang Lu, Jian-Feng Tang, Yao Wei, Xiao-Liang Wang, Yan-Bin Zhang, Hai-Liang Zhu. Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. Bioorg. Med. Chem. 19, 2011, 2688-2695.
12. Xin-Hua Liu§, Ban-Feng Ruan§, Jun Li, Hai-Liang Zhu. Synthesis and Biological Aty of Chiral Dihydropyrazole: Potential Lead for Drug Design. Mini-Rev. Med. Chem. 11, 2011, 771-821. (§Both authors contributed equally to this work)
13. Xin-Hua Liu§, Ban-Feng Ruan§, Jing-Xin Liu, Bao-An Song, Ling-Hong Jing, Jun Li, Yang Yang, Hai-Liang Zhu, Xing-Bao Qi. Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents. Bioorg. Med. Chem. Lett. 21, 2011, 2916-2920. (§Both authors contributed equally to this work)
14. Mei-Lan Sun§, Ban-Feng Ruan§, Qiong-Zhang, Zhao-Di Liu, Sheng-Li Li, Jie-Ying Wu, Bao-Kang Jin, Jia-Xiang Yang, Sheng-Yi Zhang, Yu-Peng Tian. Synthesis, crystal structures, electrochemical studies and antitumor activities of three polynuclear organotin(IV) carboxylates containing ferrocenyl moiety. J. Organomet. Chem. 696, 2011, 3180-3185. (§Both authors contributed equally to this work)
15. Ban-Feng Ruan, Yupeng Tian, Hongping Zhou, Jieying Wu, Chenhao Zhu, Jiaxiang Yang, Hailiang Zhu. Synthesis, characterization and in vitro antibacterial activity of two novel organotin(IV) complexes. Inorg. Chim. Acta. 365, 2011, 473-479.
16. Ban-Feng Ruan, Yu-Peng Tian, Hong-Ping Zhou, Jie-Ying Wu, Chen-Hao Zhu, Jia-Xiang Yang, Hai-Liang Zhu. Synthesis, characterization and in vitro antitumor activity of three organotin(IV) complexes with carbazole ligand. Inorg. Chim. Acta. 365, 2011, 302-308.

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