副教授
您的当前位置:主页 > 师资队伍 > 员工名录 > 副教授 > 正文
陈元利
阅读次数:
姓 名:
陈元利
职 称:
副教授
职 务:

所属系:
生物医学科学系
邮 箱:
chenyuanli@hfut.edu.cn
电 话:
个人学习工作简介
      陈元利副教授2009年毕业于南开大学生物科学专业,获得学士学位;2014年毕业于南开大学生物化学与分子生物学专业,获得博士学位。2015年加入合肥工业大学;2016年6月-9月,美国威斯康辛医学院,访问学者。
主要研究领域与方向
动脉粥样硬化病理机制研究;
肝脏糖脂代谢调控与相关疾病防治;
脂代谢与肿瘤。
硕士招生方向:生物化学与分子生物学、制药工程
代表性研究成果
发现组合药物疗法防治动脉粥样硬化的新策略;获得国家自然科学基金青年基金和面上项目的支持,近五年发表一作/通讯作者论文11篇、授权发明专利1项。
目前承担科研项目
1.  主持国家自然科学基金面上项目: LXR调控25HC与25HC3S合成代谢平衡与抗病毒功能,项目编号:31770863,2018年1月-2021年12月,直接60万。在研,主持。
2.  步长制药集团:龙生蛭胶囊改善糖尿病下肢血管病变的作用与机制研究,2017.5-2018.5,20万,在研,主持。
3.  另参与国际合作项目子课题、政府间国际科技创新合作重点专项等国家重大项目。
获奖情况
中国生物化学与分子生物学会脂质与脂蛋白专业委员会青年委员,多次获得会议论文奖励。
著作论文(代表作)
第一作者与通讯作者论文:
1. Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Hu W, Miao RQ, Zhu Y, Li L, Han J*, Chen Y*, Duan Y*. Functional interplay between LXR and AMPKa inhibits atherosclerosis in apoE deficient mice-A new anti-atherogenic strategy. 2018. British Journal of Pharmacology. 2018 Feb 2. doi: 10.1111/bph.14156.
2.  Zhang W#, Yang X#Chen Y#, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li L, Zhu Y, Miao RQ*, Han J*, Duan Y*. Activation of hepatic Nogo-B receptor expression—A new anti-liver steatosis mechanism of statins. BBA -Molecular and Cell Biology of Lipids.2018;1863(2):177-190.
3.  Zhang L#Chen Y#, Yang X, Yang J, Cao X, Li X, Li L, Miao QR, Hajjar DP, Duan Y, Han J. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport—an anti-atherogenic function of ERK1/2 inhibition. BBA - Molecular and Cell Biology of Lipids. 2016;1861:1180-1191.
4.  Yang X#, Zhang W#Chen Y#, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J, Duan Y. Activation of PPARg and CD36 expression--the dual pathophysiological roles of progesterone. The Journal of Biological Chemistry. 2016;291:15108-18.
5.  Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y*, Chen Y*. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes.Biochemical and Biophysical Research Communications. 2016;473:939-46.
6. Liu M, Zhang W, Li X, Han J, Chen Y*, Duan Y*. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochemical and Biophysical Research Communications. 2016;469:456-462.
7.  Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X*, Chen Y*.NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology, 2016;67:203-211.
8. Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE-/- mice.Journal of Cardiovascular Pharmacology 2015;66:189-95.
9.  Chen Y#, Duan Y#, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao QR, Xiang R, Hajjar DP, Han J. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in apoE deficient mice. Arteriosclerosis Thrombosis and Vascular Biology 2015;35:948-959.
10.  Chen Y#Liu M#, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y. Danhong Injection inhibits the development of atherosclerosis in both Apoe-/- and Ldlr-/- mice. Journal of cardiovascular Pharmacology 2014;63:441–452.
11.  Liu M#Chen Y#, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y. Danhong injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin 2014;59:1366-1373.
12.  Chen Y, Duan Y, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J. Activation of liver X receptor induces macrophage interleukin-5 expression. The Journal of Biological Chemistry 2012;287:43340-50.
13.  Duan Y#, Chen Y#, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. Peroxisome Proliferator-activated receptor g activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. The Journal of Biological Chemistry 2012;287:23667-77.
 
其他作者论文:
1. Liu Y, Wei Z, Ma X, Yang X, Chen Y, Sun L, Yu M, Ma C, Miao RQ, Hajjar DP, Han J*, Duan Y*. 25-Hydroxycholesterol induces its own production by activating cholesterol 25-hydroxylase expression in an LXR dependent mechanism. Journal of Lipid Research,2018;59(3):439-451.
2. Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao QR, Han J, Duan Y. Activation of adiponectin receptor regulates proprotein convertase subtilisin/kexin type 9 expression and inhibits lesions in apoE deficient mice. Arteriosclerosis Thrombosis and Vascular Biology. 2017;37(7):1290-1300.
3. Hu W, Zhang W, Chen Y, Rana U, Teng RJ, Duan Y, Liu Z, Zhao B, Foeckler J, Weiler H, Kallinger RE, Thomas MJ, Zhang K, Han J, Miao QR. Nogo-B receptor deficiency increases LXRa nuclear translocation and hepatic lipogenesis via AMPKa-dependent pathway.Hepatology, 2016;64:1559-1576.
4. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J, Duan Y. Inhibition of macrophage CD36 expression and cellular oxLDL accumulation by tamoxifen—A PPARg dependent mechanism. The Journal of Biological Chemistry. 2016;291(33):16977-89.
5. Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J, Duan Y. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BABL/c mice. Scientific Reports. 2016;6:27295.
6. Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J,  Duan Y. 2015. Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake. The Journal of Biological Chemistry. 2015;290:21788-99.
7. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J, Duan Y. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Scientific Reports. 2015;5:11219.
8. Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang X, Duan Y, Han J. Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II. The Journal of Biological Chemistry 2015;290:14418-29.
9. Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y, Han J. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression.Biochimica et Biophysica Acta-Molecular Basis of Disease 2015;1852:1038-1048.
10.  Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y, Han J. Inhibition of tumor growth by U0126 is associated with induction of interferon-g production.International Journal of Cancer 2015;136:771-83.
11.  Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y, Han J. Identification of interferon-g as a new molecular target of liver X receptor. Biochemical Journal 2014;459:345-354.
上一篇:戴建军
下一篇:鲍斌
管理员入口  版权所有:合肥工业大学生物与医学工程学院  备案号:皖ICP备12146036号-1  
地址:安徽省合肥市屯溪路193号  电话:0551-62901285  邮箱:hfutswyx@hfut.edu.cn